Decreased glucagon-like peptide-1 correlates with abdominal pain in patients with constipation-predominant irritable bowel syndrome
| Autor: | Na Zhang, Zheng-Yang Li, Jing Zhang, Yong-Hong Sun, Shuang Wen, Xiu-Li Sun, Xiaoming Fan |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male endocrine system Abdominal pain medicine.medical_specialty Pathology Gastroenterology Irritable Bowel Syndrome 03 medical and health sciences 0302 clinical medicine Glucagon-Like Peptide 1 Internal medicine Medicine Humans In patient Receptor Irritable bowel syndrome Aged Hepatology business.industry digestive oral and skin physiology Middle Aged medicine.disease Control subjects Glucagon-like peptide-1 Abdominal Pain 030104 developmental biology Immunohistochemistry 030211 gastroenterology & hepatology Female medicine.symptom business Constipation hormones hormone substitutes and hormone antagonists Constipation predominant irritable bowel syndrome |
| Zdroj: | Clinics and research in hepatology and gastroenterology. 41(4) |
| ISSN: | 2210-741X |
| Popis: | Summary Background and objective The glucagon-like peptide-1 (GLP-1) analog, ROSE-010, plays a critical role in alleviating abdominal pain in patients with irritable bowel syndrome (IBS); however, the underling mechanism is unclear. In the present study, we determined the serum GLP-1 level in patients with constipation-predominant IBS (IBS-C). The relationship between GLP-1 and abdominal pain was investigated. In addition, the expression of the GLP-1 receptor in the colon was determined. Methods Rectosigmoid biopsies were gathered from 38 patients with IBS-C who met the Rome III criteria, and 22 healthy controls. Abdominal pain was quantified by a validated questionnaire. Serum GLP-1 was measured by ELISA and correlated with abdominal pain scores. The presence of the GLP-1 receptor in the colonic mucosa was assessed by immunohistochemistry. Results Serum GLP-1 was substantially decreased in patients with IBS-C. Decreased serum GLP-1 had a negative correlation with the abdominal pain scores. Biopsies from patients with IBS-C revealed a significant down-regulation of the GLP-1 receptor in colonic mucosa compared with control subjects. Conclusions Decreased serum GLP-1 correlates with abdominal pain in patients with IBS-C. Decreased expression of GLP-1 and GLP-1 receptor may be the basis for alleviation of abdominal pain in patients with IBS-C by ROSE-010. |
| Databáze: | OpenAIRE |
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