Advancing our understanding of HIV co-infections and neurological disease using the humanized mouse
| Autor: | Benjamin B. Gelman, Janice J. Endsley, Mark A. Endsley, Matthew B. Huante, Kubra F. Naqvi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Hepatitis B virus
Human immunodeficiency virus (HIV) Translational research HIV Infections Mice Transgenic Disease Review Humanized mouse medicine.disease_cause Mycobacterium tuberculosis 03 medical and health sciences Gonorrhea Mice Immune system Virology Medicine Animals Humans Tuberculosis Small animal model 030304 developmental biology 0303 health sciences biology Co-infections 030306 microbiology business.industry Human immunodeficiency virus Hepatitis C virus RC581-607 biology.organism_classification Neisseria gonorrhoeae Disease Models Animal Infectious Diseases Immunology biology.protein HIV-1 Antibody Immunologic diseases. Allergy Nervous System Diseases business Co infection |
| Zdroj: | Retrovirology Retrovirology, Vol 18, Iss 1, Pp 1-14 (2021) |
| ISSN: | 1742-4690 |
| Popis: | Humanized mice have become an important workhorse model for HIV research. Advances that enabled development of a human immune system in immune deficient mouse strains have aided new basic research in HIV pathogenesis and immune dysfunction. The small animal features facilitate development of clinical interventions that are difficult to study in clinical cohorts, and avoid the high cost and regulatory burdens of using non-human primates. The model also overcomes the host restriction of HIV for human immune cells which limits discovery and translational research related to important co-infections of people living with HIV. In this review we emphasize recent advances in modeling bacterial and viral co-infections in the setting of HIV in humanized mice, especially neurological disease, and Mycobacterium tuberculosis and HIV co-infections. Applications of current and future co-infection models to address important clinical and research questions are further discussed. |
| Databáze: | OpenAIRE |
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