Acute hepatotoxicity of carbon tetrachloride. Different liver lobes response in rats with portal branch ligation
| Autor: | C. Balabaud, Paulette Bioulac-Sage, V. Lapostolle, N. More |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Necrosis Pathology and Forensic Medicine Muscle hypertrophy chemistry.chemical_compound Atrophy Internal medicine medicine Animals Carbon Tetrachloride Ligation business.industry Rats Inbred Strains medicine.disease Rats Portal System Endocrinology Liver Lobe chemistry Liver Acute Disease Carbon tetrachloride Female Steatosis medicine.symptom business Drug metabolism |
| Zdroj: | Experimental pathology. 26(1) |
| ISSN: | 0232-1513 |
| Popis: | Summary Portal branch ligation (PBL) leads to atrophy of the corresponding lobe (AL) and hypertrophy of the non ligated lobes (HL). Liver architecture of AL is preserved. In this model we assessed in rats, one month after PBL, the acute hepatotoxicity of carbon tetrachloride (CCl 4 ) given i.p. or i.v. Grading of necrosis, steatosis and ballooning demonstrated that at 24 and 48 h, AL were less severely damaged than HL and lobes of sham operated rats. Changes in hepatic blood flow, drug metabolism and/or in sinusoidal cells may represent causes involved in the partial hepato-protection. |
| Databáze: | OpenAIRE |
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