Regulation of human carbonic anhydrase I (hCAI) activity by using a photochromic inhibitor
| Autor: | Burkhard König, Neil R. Branda, Daniel Vomasta, Christina Högner |
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| Rok vydání: | 2008 |
| Předmět: |
Molecular switch
Sulfonamides Carbonic Anhydrase I Photoswitch biology Light Chemistry medicine.drug_class Photochemistry Protein Conformation food and beverages General Chemistry Thiophenes Catalysis Enzyme catalysis Photochromism Carbonic anhydrase Catalytic Domain medicine biology.protein Humans Carbonic anhydrase inhibitor Enzyme Inhibitors |
| Zdroj: | Angewandte Chemie (International ed. in English). 47(40) |
| ISSN: | 1521-3773 |
| Popis: | Photoswitchable: The activity of a dithienylethene-based human carbonic anhydrase inhibitor (hCAI) can be regulated using light. Converting the flexible, ring-open isomer of the photoswitch into the rigid, ring-closed isomer using UV light reduces the inhibition and increases the activity of hCAI by 50-fold. The inhibitor can be turned back on by using visible light, which has many advantages in biological applications. |
| Databáze: | OpenAIRE |
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