Complement coating of erythrocytes is reduced following their interaction with neutrophils in vitro without loss of complement receptor 1 (CR1)
| Autor: | H. J. Imrie, D. R. E. Jones |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Erythrocytes
biology Neutrophils Complement receptor 1 Immunology chemical and pharmacologic phenomena Antigen-Antibody Complex Original Articles Flow Cytometry Epitope In vitro Immune complex Epitopes Immune system Cell–cell interaction Complement Receptor Type 1 Phagocytosis Complement C3b Receptors Complement 3b Immunology and Allergy Humans biology.gene Receptor |
| Zdroj: | Clinical and experimental immunology. 109(1) |
| ISSN: | 0009-9104 |
| Popis: | SUMMARY We have investigated the interaction of complement-coated erythrocytes (E) with neutrophils, in vitro, to determine the effects of erythrocyte CR1. Complement-coating in vitro, to mimic immune complex uptake, caused a reduction in E-CR1, but subsequent interaction with neutrophils effected a removal of E-C3b and a return of E-CR1 to levels approximating that of uncoated erythrocytes. These data indicate that C3b, associated with immune complexes, may bind to E-CR1 in a reversible manner and that subsequent interaction with phagocytes need not necessarily result in cleavage (and loss of ) E-CR1. Further, we conclude that E-CR1 can apparently be reduced by epitope masking. |
| Databáze: | OpenAIRE |
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