Cognitive states influence dopamine-driven aberrant learning in Parkinson's disease
| Autor: | Darin R. Brown, Andrea A. Mueller, Sarah Pirio Richardson, Jacqueline R. Janowich, Ashley Wegele, Jacqueline Story-Remer, James F. Cavanagh |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Parkinson's disease Dopamine Cognitive Neuroscience Experimental and Cognitive Psychology Neuropsychological Tests Affect (psychology) Article 050105 experimental psychology Developmental psychology 03 medical and health sciences Cognition 0302 clinical medicine medicine Humans Learning Cognitive Dysfunction 0501 psychology and cognitive sciences Young adult Aged Aged 80 and over Volition (psychology) Motivation Parkinsonism 05 social sciences Dopaminergic Parkinson Disease Middle Aged medicine.disease Neuropsychology and Physiological Psychology Female Psychology Psychomotor Performance 030217 neurology & neurosurgery Clinical psychology medicine.drug |
| Zdroj: | Cortex. 90:115-124 |
| ISSN: | 0010-9452 |
| DOI: | 10.1016/j.cortex.2017.02.021 |
| Popis: | Individual differences in dopaminergic tone underlie tendencies to learn from reward versus punishment. These effects are well documented in Parkinson's patients, who vacillate between low and high tonic dopaminergic states as a function of medication. Yet very few studies have investigated the influence of higher-level cognitive states known to affect downstream dopaminergic learning in Parkinson's patients. A dopamine-dependent cognitive influence over learning would provide a candidate mechanism for declining cognitive integrity and motivation in Parkinson's patients. In this report we tested the influence of two high-level cognitive states (cost of conflict and value of volition) that have recently been shown to cause predictable learning biases in healthy young adults as a function of dopamine receptor subtype and dopaminergic challenge. It was hypothesized that Parkinson's patients OFF medication would have an enhanced cost of conflict and a decreased value of volition, and that these effects would be remediated or reversed ON medication. Participants included N = 28 Parkinson's disease patients who were each tested ON and OFF dopaminergic medication and 28 age- and sex-matched controls. The expected cost of conflict effect was observed in Parkinson's patients OFF versus ON medication, but only in those that were more recently diagnosed ( |
| Databáze: | OpenAIRE |
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