The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and Cancer
| Autor: | Monica N Morgan, Chloe-Anne Martinez, Sapir Dvuchbabny, Peter A. Cistulli, Kristina M. Cook, Bernadette Kerr |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
tumor DNA repair Circadian clock Review Biology medicine.disease_cause Causes of cancer 03 medical and health sciences 0302 clinical medicine circadian disruption medicine cancer Circadian rhythm General Environmental Science hypoxia CLOCK clock 030104 developmental biology circadian rhythms Tumor progression 030220 oncology & carcinogenesis Cancer cell General Earth and Planetary Sciences Carcinogenesis Neuroscience |
| Zdroj: | Clocks & Sleep |
| ISSN: | 2624-5175 |
| Popis: | Circadian rhythms regulate many physiological and behavioral processes, including sleep, metabolism and cell division, which have a 24-h oscillation pattern. Rhythmicity is generated by a transcriptional–translational feedback loop in individual cells, which are synchronized by the central pacemaker in the brain and external cues. Epidemiological and clinical studies indicate that disruption of these rhythms can increase both tumorigenesis and cancer progression. Environmental changes (shift work, jet lag, exposure to light at night), mutations in circadian regulating genes, and changes to clock gene expression are recognized forms of disruption and are associated with cancer risk and/or cancer progression. Experimental data in animals and cell cultures further supports the role of the cellular circadian clock in coordinating cell division and DNA repair, and disrupted cellular clocks accelerate cancer cell growth. This review will summarize studies linking circadian disruption to cancer biology and explore how such disruptions may be further altered by common characteristics of tumors including hypoxia and acidosis. We will highlight how circadian rhythms might be exploited for cancer drug development, including how delivery of current chemotherapies may be enhanced using chronotherapy. Understanding the role of circadian rhythms in carcinogenesis and tumor progression will enable us to better understand causes of cancer and how to treat them. |
| Databáze: | OpenAIRE |
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