Preparation of Calcipotriol Emulsion Using Bacterial Exopolysaccharides as Emulsifier for Percutaneous Treatment of Psoriasis Vulgaris
| Autor: | Hairong Chu, Fang Yan, Ruiteng Song, Min Cheng, Bo Song, Yuzhen Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Drug food.ingredient Bacillus amyloliquefaciens media_common.quotation_subject Mannose calcipotriol 02 engineering and technology Administration Cutaneous Article Catalysis Inorganic Chemistry Mice 03 medical and health sciences chemistry.chemical_compound food Calcitriol In vivo Psoriasis medicine Animals Food science Physical and Theoretical Chemistry Molecular Biology Calcipotriol Spectroscopy media_common emulsion biology Chemistry Sunflower oil exopolysaccharides Polysaccharides Bacterial Organic Chemistry General Medicine psoriasis 021001 nanoscience & nanotechnology medicine.disease biology.organism_classification Computer Science Applications 030104 developmental biology Emulsifying Agents Emulsion Dermatologic Agents 0210 nano-technology |
| Zdroj: | International Journal of Molecular Sciences Volume 21 Issue 1 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms21010077 |
| Popis: | An exopolysaccharides/calcipotriol (EPS/CPT) emulsion was prepared using bacterial EPS as emulsifier, sunflower oil as an oil phase and CPT as the loaded drug, and the effect of this emulsion on psoriasis vulgaris treatment was evaluated. An EPS composed of mannose (70.56%) and glucose (29.44%) was obtained from the marine mangrove bacteria Bacillus amyloliquefaciens ZWJ (Zhu Wenjing) strain. The EPS has significant emulsifying activity at the concentration of 1.5%. The prepared EPS/CPT emulsion has small and stable particle size, with a drug content of 0.00492%, and good spreading properties. The in vitro drug release results revealed that the emulsion showed a certain sustained release effect. In vitro and in vivo animal experiments show that the EPS/CPT emulsion can effectively treat psoriasis vulgaris by increasing the accumulation of CPT in psoriatic skin lesions and reducing the levels of inflammatory cells and inflammatory factors (TNF and IL6). Additionally, it has a certain effect on reducing the side effects associated with CPT. This study lays a foundation for the research of EPS in the topical application of medical materials and treatment of psoriasis. |
| Databáze: | OpenAIRE |
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