Hemicentins: What have we learned from worms?
| Autor: | Chun Dong, Xuehong Xu, Bruce E. Vogel, Joaquin M. Muriel |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Extracellular Matrix Proteins
Calcium-Binding Proteins Cell Cell migration Cell Biology Anatomy Biology biology.organism_classification Cell junction Fibulin Cell biology Extracellular matrix medicine.anatomical_structure Mutation Cell Adhesion medicine Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Molecular Biology Gene Function (biology) |
| Zdroj: | Cell Research. 16:872-878 |
| ISSN: | 1748-7838 1001-0602 |
| Popis: | Hemicentins are conserved extracellular matrix proteins discovered in Caenorhabditis elegans, with orthologs in all vertebrate species including human and mouse. Hemicentins share a single, highly conserved amino-terminal von Willebrand A domain, followed by a long (>40) stretch of immunoglobulin repeats, multiple tandem epidermal growth factors and a fibulin-like carboxy-terminal module. C. elegans has a single hemicentin gene that has pleiotropic functions in transient cell contacts that are required for cell migration and basement membrane invasion and in stable contacts at hemidesmosome-mediated cell junctions and elastic fiber-like structures. Here, we summarize what is known about the function of hemicentin in C. elegans and discuss implications for hemicentin function in other species. |
| Databáze: | OpenAIRE |
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