Next-generation approaches to understand and combat the antibiotic resistome
| Autor: | Terence S. Crofts, Andrew J. Gasparrini, Gautam Dantas |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Carbapenem Gene Transfer Horizontal medicine.drug_class 030106 microbiology Antibiotics Drug resistance Biology Communicable Diseases Emerging Microbiology Article 03 medical and health sciences Antibiotic resistance Drug Resistance Multiple Bacterial medicine Humans Phylogeny Bacteria General Immunology and Microbiology Resistance (ecology) business.industry High-Throughput Nucleotide Sequencing Anti-Bacterial Agents Resistome Biotechnology 030104 developmental biology Infectious Diseases Genes Bacterial Metagenomics Colistin Metagenome business medicine.drug |
| Zdroj: | Nature Reviews Microbiology. 15:422-434 |
| ISSN: | 1740-1534 1740-1526 |
| DOI: | 10.1038/nrmicro.2017.28 |
| Popis: | Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of antibiotic resistance genes between habitats, the rapid global spread of genes that confer resistance to carbapenem, colistin and quinolone antibiotics illustrates the dire clinical and societal consequences of such events. Over time, the study of antibiotic resistance has grown from focusing on single pathogenic organisms in axenic culture to studying antibiotic resistance in pathogenic, commensal and environmental bacteria at the level of microbial communities. As the study of antibiotic resistance advances, it is important to incorporate this comprehensive approach to better inform global antibiotic resistance surveillance and antibiotic development. It is increasingly becoming apparent that although not all resistance genes are likely to geographically and phylogenetically disseminate, the threat presented by those that are is serious and warrants an interdisciplinary research focus. In this Review, we highlight seminal work in the resistome field, discuss recent advances in the studies of resistomes, and propose a resistome paradigm that can pave the way for the improved proactive identification and mitigation of emerging antibiotic resistance threats. |
| Databáze: | OpenAIRE |
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