Update on gastric cancer treatments and gene therapies
| Autor: | Laura Papucci, Elisa Giommoni, Lucia Magnelli, Nicola Schiavone, Fabio Cianchi, Sara Peri, Ileana Skalamera, Alessio Biagioni |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment Genetic enhancement Drug resistance 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Internal medicine medicine Humans Gene Randomized Controlled Trials as Topic Chemotherapy Gastric cancer . Chemotherapy . Metastases . Gene therapy . CRISPR business.industry Incidence (epidemiology) Cancer Genetic Therapy medicine.disease Review article 030104 developmental biology 030220 oncology & carcinogenesis Gastrectomy business |
| Zdroj: | Cancer metastasis reviews. 38(3) |
| ISSN: | 1573-7233 |
| Popis: | Gastric cancer is an active topic of clinical and basic research due to high morbidity and mortality. To date, gastrectomy and chemotherapy are the only therapeutic options for gastric cancer patients, but drug resistance, either acquired or primary, is the main cause for treatment failure. Differences in development and response to cancer treatments have been observed among ethnically diverse GC patient populations. In spite of major incidence, GC Asian patients have a significantly better prognosis and response to treatments than Caucasian ones due to genetic discordances between the two populations. Gene therapy could be an alternative strategy to overcome such issues and especially CRISPR/Cas9 represents one of the most intriguing gene-editing system. Thus, in this review article, we want to provide an update on the currently used therapies for the treatment of advanced GC. Graphical abstract. |
| Databáze: | OpenAIRE |
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