Regioselective Iridium-Catalyzed Asymmetric Monohydrogenation of 1,4-Dienes
| Autor: | Napasawan Chumnanvej, Haibo Wu, Jianguo Liu, Giulia De Seriis, Pher G. Andersson, Thishana Singh, Suppachai Krajangsri |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Organisk kemi
Silylation 010405 organic chemistry Chemistry Organic Chemistry Enantioselective synthesis Regioselectivity chemistry.chemical_element Substrate (chemistry) General Chemistry 010402 general chemistry 01 natural sciences Biochemistry Catalysis 0104 chemical sciences Colloid and Surface Chemistry Organic chemistry Iridium Enantiomeric excess |
| Popis: | A highly efficient regio- and enantioselective monohydrogenation of 1,4-dienes has been realized using an iridium catalyst with a chiral N,P-ligand under mild conditions. The substrate scope was studied and included both unfunctionalized as well as functionalized substituents on the meta- or para-position. Substrates having substituents with functionalities such as silyl protected alcohols or ketals were monohydrogenated in high regioselectivity and high enantiomeric excess (up to 98% ee). |
| Databáze: | OpenAIRE |
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