Clinical features and risk factors for death in acute undifferentiated fever: A prospective observational study in rural community hospitals in six states of India
| Autor: | Kristine Mørch, Anand Manoharan, Sara Chandy, Ashita Singh, Cijoy Kuriakose, Suvarna Patil, Anil Henry, Novin Chacko, Gerardo Alvarez-Uria, Joel Nesaraj, Bjørn Blomberg, Siby Kurian, Christel Gill Haanshuus, George Vasanthan Antony, Nina Langeland, Dilip Mathai |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Transactions of The Royal Society of Tropical Medicine and Hygiene. 117:91-101 |
| ISSN: | 1878-3503 0035-9203 |
| Popis: | Background Acute undifferentiated fever (AUF) ranges from self-limiting illness to life-threatening infections, such as sepsis, malaria, dengue, leptospirosis and rickettsioses. Similar clinical presentation challenges the clinical management. This study describes risk factors for death in patients hospitalized with AUF in India. Methods Patients aged ≥5 y admitted with fever for 2–14 d without localizing signs were included in a prospective observational study at seven hospitals in India during 2011–2012. Predictors identified by univariate analysis were analyzed by multivariate logistic regression for survival analysis. Results Mortality was 2.4% (37/1521) and 46.9% (15/32) died within 2 d. History of heart disease (p=0.013), steroid use (p=0.011), altered consciousness (p Conclusions Bleeding, cerebral dysfunction, respiratory failure and oliguria at admission, suggestive of severe organ failure secondary to systemic infection, were predictors of death. Almost half of the patients who died, died shortly after admission, which, together with organ failure, suggests that delay in hospitalization and, consequently, delayed treatment, contribute to death from AUF. |
| Databáze: | OpenAIRE |
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