Keep PNUTS in your heart
| Autor: | James R. Pancoast, Francesco S. Loffredo, Richard T. Lee |
|---|---|
| Přispěvatelé: | Loffredo, Francesco S., Pancoast, James R., Lee, Richard T. |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Aging Microarray DNA damage Physiology Regulator Biology Bioinformatics Internal medicine microRNA medicine Animals Myocardial infarction Animal Myocardium MicroRNA Heart medicine.disease humanities Cardiovascular physiology Telomere MicroRNAs Endocrinology Physiological Aging Gene Expression Regulation Cardiology and Cardiovascular Medicine |
| Zdroj: | Circulation research. 113(2) |
| ISSN: | 1524-4571 |
| Popis: | Aging is a major factor in many cardiovascular diseases. The molecular factors that regulate age-related changes in cardiac physiology and contribute to the increased cardiovascular risk in the elderly are not fully understood. A study recently published in Nature suggests a specific role for microRNAs (miRNAs) in regulating cardiac aging and function, challenging the concept that aging is an inevitable process in the heart. Aging is an evolutionarily conserved yet poorly understood process that leads to deterioration of many physiological functions during the lifespan of an organism.1 Aging increases the risk of cardiovascular diseases and leads to worse clinical outcomes.2 Elderly patients have an increased risk of acute myocardial infarction (MI) and an increase in both in-hospital and postdischarge mortality.3 The capability of the adult mammalian heart to replenish its cardiomyocyte pool both during physiological aging and in response to injury has now been definitively established.4,5 However, cardiomyocyte refreshment occurs at a low rate (≈1%/y) even in youth and seems to slow with advancing age.4 Recent evidence suggests that some of the aging hallmarks, like age-related cardiac hypertrophy, are regulated by hormones and can be reversed.6 The molecular mechanisms that regulate cardiac aging are complex and not yet completely understood. In the March 31, 2013, issue of Nature , Boon et al7 describe a new molecular pathway that regulates cardiac aging. Using a microarray approach, the authors identified several miRNAs, including miR-34a, that change with age. miR-34a increases with age and acts as a regulator of telomere shortening, DNA damage, and apoptosis in cardiomyocytes, whereas its inhibition improves functional recovery after acute MI (Figure). miRNAs … |
| Databáze: | OpenAIRE |
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