Altered Macrophage Antigen-Presenting Cell Function Following Friend Leukemia Virus Infection
| Autor: | Marlena A. Moors, Kenneth J. Blank, Karen K. Klyczek, Sylvia M. Jones, Qin Ryan |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Interleukin 2
T-Lymphocytes Immunology Antigen presentation Antigen-Presenting Cells Lymphocyte Activation Immunofluorescence Virus Mice Phagocytosis Virology Murine leukemia virus medicine Animals Macrophage Antigen-presenting cell Cells Cultured Mice Inbred BALB C MHC class II Leukemia Experimental medicine.diagnostic_test biology Macrophages Histocompatibility Antigens Class II biology.organism_classification Molecular biology Friend murine leukemia virus biology.protein Interleukin-2 Pinocytosis RNA Viral Molecular Medicine Female medicine.drug |
| Zdroj: | Viral Immunology. 5:201-211 |
| ISSN: | 1557-8976 0882-8245 |
| Popis: | To investigate the mechanism by which Friend leukemia virus (FV) causes immunosuppression, the ability of peritoneal macrophages to mediate antigen-specific T-cell activation following FV infection was examined. Decreased IL-2 production was observed when antigen-primed T cells were cultured with antigen-pulsed macrophages from mice infected with FV, compared to T cells cultured with macrophages from control mice. Macrophages from FV-infected mice demonstrated decreased phagocytic and pinocytic activity, suggesting that antigen uptake may be impaired in these cells. In addition, FV-infected mice had decreased numbers of MHC class II positive macrophages compared to uninfected controls, as measured by immunofluorescence. The alterations in antigen uptake and class II expression observed in macrophages from FV-infected mice may be the result of infection of these cells by FV, which was demonstrated by in situ hybridization using a FV-specific probe. The ability of FV to infect and modulate the functions of macrophages may account, at least in part, for the immunosuppression observed in FV-infected mice. |
| Databáze: | OpenAIRE |
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