Intestinal dysbiosis activates renal renin-angiotensin system contributing to incipient diabetic nephropathy
| Autor: | Bi Cheng Liu, Xiong Z. Ruan, Chen Chen Lu, Kun Ling Ma |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Context (language use) Intestinal dysbiosis Review Gut microbiota Gut flora Kidney digestive system Incipient diabetic nephropathy Diabetic nephropathy Renin-Angiotensin System 03 medical and health sciences Human health Diabetes mellitus Renin–angiotensin system medicine Humans Diabetic Nephropathies biology business.industry diabetic nephropathy General Medicine medicine.disease biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology Immunology Dysbiosis business |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| Popis: | Considerable interest nowadays has focused on gut microbiota owing to their pleiotropic roles in human health and diseases. This intestinal community can arouse a variety of activities in the host and function as "a microbial organ" by generating bioactive metabolites and participating in a series of metabolism-dependent pathways. Alternations in the composition of gut microbiota, referred to as intestinal dysbiosis, are reportedly associated with several diseases, especially diabetes mellitus and its complications. Here we focus on the relationship between gut microbiota and diabetic nephropathy (DN), as the latter is one of the major causes of chronic kidney diseases. The activation of renin angiotensin system (RAS) is a critical factor to the onset of DN, and emerging data has demonstrated a provoking and mediating role of gut microbiota for this system in the context of metabolic diseases. The purpose of the current review is to highlight some research updates about the underlying interplay between gut microbiota, their metabolites, and the development and progression of DN, along with exploring innovative approaches to targeting this intestinal community as a therapeutic perspective in clinical management of DN patients. |
| Databáze: | OpenAIRE |
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