Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of stomach cancer: a hospital-based case-control study in Japan
| Autor: | Shusuke Natsukawa, Hiromi Sakamoto, Yoichi Koizumi, Motoki Iwasaki, Teruhiko Yoshida, Kozo Shaura, Tetsuya Otani, Yoshio Kasuga, Shoichiro Tsugane, Minatsu Kobayashi |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Arylamine N-Acetyltransferase Gastroenterology Diet Surveys Young Adult Japan Polymorphism (computer science) Cytochrome P-450 CYP1A2 Heterocyclic Compounds Stomach Neoplasms Internal medicine Fish Products medicine Cytochrome P-450 CYP1A1 Humans Young adult Amines Stomach cancer Aged chemistry.chemical_classification Polymorphism Genetic business.industry Case-control study CYP1A2 Imidazoles General Medicine Odds ratio Middle Aged medicine.disease Confidence interval Meat Products Logistic Models Oncology chemistry Heterocyclic amine Case-Control Studies Carcinogens Female business Hair |
| Zdroj: | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 12(4) |
| ISSN: | 1436-3305 |
| Popis: | Although the associations between grilled (broiled) or barbecued meats or fish intake and stomach cancer risk have been investigated, the evidence implicating heterocyclic amine (HCA) intake as a cause of stomach cancer is limited. We conducted a case-control study to investigate the association between HCA intake and stomach cancer risk. We also investigated the possible effect of genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 on stomach cancer. HCA exposure data were assessed using a self-administered food-frequency questionnaire, and estimated HCA intake was verified by measuring 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) values in human hair. A total of 149 cases and 296 controls were included in the analyses. Odds ratios (ORs) were calculated, using conditional logistic regression analysis, to compare intake levels between the first and third tertiles. Results showed no statistically significant increase in the risk of stomach cancer with respect to total HCA intake (OR, 1.11; 95% confidence interval [CI], 0.36, 3.49), or with respect to the intake of individual HCAs; namely, PhIP, 2-amino-3, 4-dimethylimidazo[4,5-f]quinoline (MeIQ), and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). Genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 did not influence the association of HCA intake with stomach cancer. In the present study, with a limited sample size of subjects with low HCA exposure, no association was found between HCA intake and stomach cancer, nor was there any evidence of any influence by genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 on the risk of stomach cancer. |
| Databáze: | OpenAIRE |
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