Corrigendum: Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions
| Autor: | Melissa Malvaez, Venuz Y. Greenfield, Alice S. Wang, Allison M. Yorita, Lili Feng, Kay E. Linker, Harold G. Monbouquette, Kate M. Wassum |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Neurotransmitter Agents Multidisciplinary Neurosciences Glutamic Acid Amygdala Anticipation Psychological Corrigenda Adaptation Physiological Choice Behavior Brain Disorders Extinction Psychological Rats Other Physical Sciences Mental Health Reward Animals Conditioning Operant Rats Long-Evans Biochemistry and Cell Biology Cues |
| Zdroj: | Scientific Reports Malvaez, Melissa; Greenfield, Venuz Y; Wang, Alice S; Yorita, Allison M; Feng, Lili; Linker, Kay E; et al.(2016). Corrigendum: Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions.. Scientific reports, 6(1), 20891. doi: 10.1038/srep20891. UCLA: Retrieved from: http://www.escholarship.org/uc/item/8nv955cp Scientific reports, vol 6, iss 1 |
| ISSN: | 2045-2322 |
| Popis: | Environmental stimuli have the ability to generate specific representations of the rewards they predict and in so doing alter the selection and performance of reward-seeking actions. The basolateral amygdala participates in this process, but precisely how is unknown. To rectify this, we monitored, in near-real time, basolateral amygdala glutamate concentration changes during a test of the ability of reward-predictive cues to influence reward-seeking actions (Pavlovian-instrumental transfer). Glutamate concentration was found to be transiently elevated around instrumental reward seeking. During the Pavlovian-instrumental transfer test these glutamate transients were time-locked to and correlated with only those actions invigorated by outcome-specific motivational information provided by the reward-predictive stimulus (i.e., actions earning the same specific outcome as predicted by the presented CS). In addition, basolateral amygdala AMPA, but not NMDA glutamate receptor inactivation abolished the selective excitatory influence of reward-predictive cues over reward seeking. These data support [corrected] the hypothesis that transient glutamate release in the BLA can encode the outcome-specific motivational information provided by reward-predictive stimuli. |
| Databáze: | OpenAIRE |
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