Terbutaline vs Albuterol for Out-of-hospital Respiratory Distress: Randomized, Double-blind Trial
| Autor: | William J. Zehner, Jay M. Scott, Patsy M. Iannolo, Thomas E. Terndrup, Alan Ungaro |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Emergency Medical Services medicine.medical_specialty Respiratory rate Visual analogue scale Injections Subcutaneous Terbutaline Peak Expiratory Flow Rate Severity of Illness Index law.invention Double-Blind Method Randomized controlled trial law Administration Inhalation Severity of illness medicine Humans Albuterol Lung Diseases Obstructive Prospective Studies Respiratory system Aged Asthma Respiratory distress business.industry General Medicine Middle Aged medicine.disease Bronchodilator Agents Dyspnea Anesthesia Emergency Medicine Physical therapy Female business medicine.drug |
| Zdroj: | Academic Emergency Medicine. 2:686-691 |
| ISSN: | 1553-2712 1069-6563 |
| Popis: | Objective: To determine the efficacy and safety of single doses of subcutaneous terbutaline (terb) or nebulized albuterol (alb) during out-of-hospital treatment for respiratory distress from asthma or chronic obstructive pulmonary disease. Methods: Patients aged >18 years who had respiratory distress were enrolled in a double-placebo, double-blind, randomized trial. Paramedics measured respiratory severity using an empiric score [respiratory rate, wheezing, speech, and peak expiratory flow rate (PEFR)], and the patients rated their own respiratory distress using a visual analog scale (VAS). The patients received 02 plus alb (2.5 mg) and saline injection (n = 40) or terb (0.25 mg) and saline aerosol (n = 43). Results: The groups were similar with respect to age, gender, initial empiric scores (median score 9 for both groups), PEFRs (89 ± 84 L/min, mean ± SD, for alb vs 97 ± 84 L/min for terb), and respiratory distress VAS scores. Both groups showed significant improvement in their respiratory distress VAS scores by the time of ED arrival. The alb group had a greater improvement in respiratory distress VAS score than did the terb group (p < 0.05). Empiric scores, PEFR scores, and hospital admission frequencies were not significantly different. No complication was observed. Conclusion: The out-of-hospital administration of either aerosolized alb or subcutaneous terb reduced respiratory severity. Albuterol provided greater subjective improvement in respiratory distress. |
| Databáze: | OpenAIRE |
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