Proposal for a Monitoring Concept for Veterinary Medicinal Products with PBT Properties, Using Parasiticides as a Case Study
| Autor: | Karen Duis, Jörg Römbke |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Veterinary medicine
Chemical Health and Safety dung organisms Computer science Health Toxicology and Mutagenesis toxicity 04 agricultural and veterinary sciences persistence 010501 environmental sciences post-authorization monitoring Toxicology lcsh:Chemical technology 01 natural sciences Article Food chain Technical performance bioaccumulation field study VMP Environmental monitoring 040103 agronomy & agriculture 0401 agriculture forestry and fisheries lcsh:TP1-1185 0105 earth and related environmental sciences |
| Zdroj: | Toxics; Volume 6; Issue 1; Pages: 14 Toxics, Vol 6, Iss 1, p 14 (2018) Toxics |
| ISSN: | 2305-6304 |
| DOI: | 10.3390/toxics6010014 |
| Popis: | The aim of this work is to prepare a proposal for the post-authorization monitoring (PAM) of veterinary medicinal products (VMP), in particular parasiticides. Such a monitoring might especially be useful for parasiticides identified as Persistence Bioaccumulation Toxicity (PBT) substances, i.e., chemicals that are toxic (T), persist in the environment (P) and bioaccumulate (B) in food chains and, thus, pose a hazard to ecosystems. Based on a literature search, issues to be considered when performing such a PAM are discussed (e.g., residue analysis, compartments to be included, selection of organisms and the duration of monitoring studies). The outcome of this discussion is that—and despite that there are huge challenges in detail (e.g., in terms of analytical chemistry or taxonomy)—the technical performance of such a PAM is not the main problem, since most of the chemical and biological methods to be used are well-known (partly even standardized) or could be adapted. However, it is very difficult to define in detail where and when a monitoring should be performed. The main problem is to link exposure to effects of a certain parasiticide in a way that any impact can directly be related to the use of this parasiticide. Therefore, a “Targeted Environmental Monitoring” (TEM) is proposed, which is essentially a combination between a field study and a PAM. |
| Databáze: | OpenAIRE |
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