Central sympathetic reactivity inhibited by indoramin
| Autor: | Meredith A. Davison, Michael C. Koss |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Indoles Sympathetic Nervous System Stimulation Blood Pressure Pharmacology Inhibitory postsynaptic potential Indoramin Internal medicine medicine Animals Reactivity (psychology) Dose-Response Relationship Drug Chemistry Brain Yohimbine Cns effects Endocrinology Hypothalamus Electrodermal response Cats Female medicine.drug |
| Zdroj: | European journal of pharmacology. 68(2) |
| ISSN: | 0014-2999 |
| Popis: | The action of indoramin on central autonomic activity was investigated using the sympathetic-cholinergic electrodermal response system. Indoramin (0.33–10 mg/kg, i.v.) significantly reduced the amplitude of electrodermal responses (EDR) evoked by stimulation of the hypothalamus in a dose-related manner. The CNS effects of indoramin on the EDR were partially antagonized by yohombine pretreatment. These results demonstrate that indoramin reduces central sympathetic reactivity and suggest that an α-adrenergic inhibitory mechanism may be involved. |
| Databáze: | OpenAIRE |
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