Evaluating Dose-response of Cataract Induction in Radiotherapy of Head and Neck Cancers Patients
| Autor: | Amir Mohammad Arefpour, Karim Khoshgard, Abbas Haghparast, Negin Farshchian, H Aryaei Tabar, M Bahrami |
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| Rok vydání: | 2021 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty genetic structures lcsh:R895-920 medicine.medical_treatment Radiography Cataract formation Bioengineering Radiation Dosage Cataract 030218 nuclear medicine & medical imaging Ionizing radiation 03 medical and health sciences 0302 clinical medicine medicine Radiology Nuclear Medicine and imaging Head and neck Radiation treatment planning Dose delivery Radiotherapy Radiological and Ultrasound Technology business.industry Eye Lens Absorbed Dose Repeated measures design Radiation therapy Head and Neck Cancers 030220 oncology & carcinogenesis Original Article Radiology business |
| Zdroj: | Journal of Biomedical Physics & Engineering Journal of Biomedical Physics and Engineering, Vol 11, Iss 1, Pp 9-16 (2021) |
| ISSN: | 2251-7200 |
| DOI: | 10.31661/jbpe.v0i0.834 |
| Popis: | Background Head and neck cancers are currently the most common types of cancers. 3D-conformal radiation therapy is the most common dose delivery technique for head and neck cancers. Eye Lens is a radio sensitive structure and cataract formation as a visual disorder associated with exposure to ionizing radiation which is documented. Objective Determining the radiation dose to eye lens during head and neck radiography and estimating the probability of cataract induction are essential. Material and methods This experimental study was performed on 14 patients with head and neck cancers through experimental study analysis. The maximum opacity of the eyes lens were measured by pentacamTM before radiation therapy. CT data of patients were transmitted to Isogray treatment planning Software, and dose calculations for each patient was performed. At the end of radiation treatment, 3 and 6 months after radiotherapy, the eye lens opacity of the patients was assessed. Results Overall, 28 lenses were studied. Statistical one sample K- S test proved normality of obtained data. Using repeated measures test, the relation before and 3 months after radiotherapy, as well as the relationship before and 6 months after radiotherapy proved a significant relationship. Conclusion The opacity caused by radiation in eyes is a non-statistical and linear-quadratic response curve with no threshold. This opacity can also appear within 3 months after completion of radiation therapy. |
| Databáze: | OpenAIRE |
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