Exploitation of novel gum Prunus cerasoides as mucoadhesive beads for a controlled-release drug delivery
| Autor: | T. Veenus Seelan, Narra Kishore, Henry Linda Jeeva Kumari, H. Lalhlenmawia, K. Thanzami, Lalduhsanga Pachuau, Kandasamy Ruckmani, P. Selvamani |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Alginates
Surface Properties 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Dosage form Drug Delivery Systems Glucuronic Acid Structural Biology Plant Gums Spectroscopy Fourier Transform Infrared Mucoadhesion Particle Size Molecular Biology Zero order Controlled release drug Chromatography Mucous Membrane biology Calorimetry Differential Scanning Chemistry Hexuronic Acids General Medicine Diclofenac Sodium 021001 nanoscience & nanotechnology biology.organism_classification Controlled release Natural gum Microspheres 0104 chemical sciences Drug Liberation Delayed-Action Preparations Thermogravimetry Prunus cerasoides Prunus 0210 nano-technology |
| Zdroj: | International journal of biological macromolecules. 85 |
| ISSN: | 1879-0003 |
| Popis: | The present study deals with the formulation of pH-sensitive mucoadhesive beads using natural gum isolated from Prunus cerasoides (PC) in combination with sodium alginate (SA) for the controlled release of diclofenac sodium (DS). PC and SA composite (PC-SA), DS loaded SA (DS-SA) and DS loaded PC-SA (DS-PC-SA) beads were prepared by ionotropic gelation method. The absence of interaction between DS and PC-SA was shown by FTIR, DSC and TGA analyses. The optimized DS-PC-SA formulation exhibited mucoadhesive property and the controlled release of DS was achieved 68% in 12h. The in vitro release kinetics follows zero order with anomalous diffusion mechanism. Therefore, the formulated mucoadhesive beads with the novel gum are preferable for the controlled release of DS by prolonging the residence time of the drug in the gastrointestinal tract, overcoming the problems associated with the immediate release dosage forms of DS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect