Hormone replacement therapy, renal function and heart ultrasonographic parameters in postmenopausal women: an observational study
| Autor: | Mt Caputo, M. Comassi, Anna Solini, Edoardo Vitolo |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
CHRONIC KIDNEY-DISEASE
medicine.medical_specialty Hormone Replacement Therapy medicine.medical_treatment Heart Ventricles Renal function URIC-ACID Left ventricular hypertrophy GLOMERULAR-FILTRATION-RATE Excretion LEFT-VENTRICULAR HYPERTROPHY HYPERTENSIVE PATIENTS Internal medicine medicine Humans Heart Atria DIABETIC KIDNEY Aorta Aged CARDIOVASCULAR-DISEASE COLLABORATIVE METAANALYSIS POPULATION COHORTS PRIMARY PREVENTION Ejection fraction business.industry Hormone replacement therapy (menopause) Estrogens Heart General Medicine Middle Aged medicine.disease Menopause Postmenopause Endocrinology Cross-Sectional Studies Cardiovascular Diseases Echocardiography Cohort Cardiology Regression Analysis Female business Biomarkers Hormone Glomerular Filtration Rate |
| Zdroj: | International journal of clinical practice. 69(6) |
| ISSN: | 1742-1241 |
| Popis: | A certain degree of impaired kidney function is related to an increased cardiovascular risk. The cardiovascular protection exerted in the postmenopausal state by the hormone replacement therapy (HRT) is debated. No studies have so far explored the relationship between menopause, renal function and cardiovascular risk profile in healthy menopausal women in relation with HRT.A total of 362 postmenopausal healthy women with normal albumin excretion rate were recruited and divided into two groups (HRT+ and HRT-) according to the presence or absence of HRT. All participants underwent a complete routine biochemical analyses and an echocardiogram.Clinical characteristics of the two groups were similar, but HRT+ showed a significantly higher estimated glomerular filtration rate (GFR; by CKD-EPI formula). Regarding the heart ultrasonography, HRT+ had a significantly lower size of the aortic root and left atrium diameter (p = 0.038 and p = 0.012, respectively); no differences were found in the ejection fraction and Left Ventricular Mass Index (LVMI). In the whole study group, eGFR correlated inversely with LVMI and with the size of the aortic root (both p0.0001), being GFR the only determinant of the former by a stepwise regression. Dividing the study population according to an eGFR cut-off (80 and80 ml/min/1.73 m(2));80 women, in comparison with80, showed a significantly lower LVMI and lower size of aortic bulb, further reduced in the HRT+.In a cohort of healthy, drug-naïve, postmenopausal women, HRT seems to positively affect glomerular filtration and is associated with lower values of left ventricular mass and aortic root size, thus offering a further mechanism through female hormones exert cardioprotection. |
| Databáze: | OpenAIRE |
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