Influence of dietary fiber from coconut kernel (Cocos nucifera) on the 1,2-dimethylhydrazine-induced lipid peroxidation in rats
| Autor: | Leelamma S, Venugopal P. Menon, B.S.H. Thampi, Manoj G Pillai |
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| Rok vydání: | 1998 |
| Předmět: |
endocrine system
medicine.medical_specialty Nutrition and Dietetics Antioxidant Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry food and beverages Glutathione Biology Biochemistry Lipid peroxidation Superoxide dismutase 1 2-Dimethylhydrazine chemistry.chemical_compound Neutral Detergent Fiber Endocrinology chemistry Catalase Internal medicine medicine biology.protein Fiber Molecular Biology |
| Zdroj: | The Journal of nutritional biochemistry. 10(9) |
| ISSN: | 0955-2863 |
| Popis: | The influence of dietary fiber from coconut kernel isolated by the neutral detergent fiber method on the antioxidant status in rats treated with the colon specific carcinogen 1,2-dimethylhydrazine (DMH) was studied in rats fed a high-fat diet for 15 weeks. The DMH-treated fiber group showed higher levels of lipid peroxides than the control group treated with DMH at the preneoplastic and neoplastic stages. Free fatty acid levels were found to decrease significantly in the DMH-treated control group, whereas it was near normal in the fiber groups. Superoxide dismutase and catalase activity also were found to be increased in the liver, intestine, proximal colon, and distal colon. Glutathione levels in all the tissues studied showed significant decreases in the fiber group. The results suggest that coconut kernel fiber can protect cells from loss of oxidative capacity with the administration of the procarcinogen DMH. |
| Databáze: | OpenAIRE |
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