A study of β-thromboglobulin and platelet factor-4 plasma levels in steady state sickle cell patients
| Autor: | A. Travlou, Konstantinos Konstantopoulos, M. Toumbis, D. Douratsos, A. Kasfiki, S. Adamides |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Heterozygote medicine.medical_specialty Adolescent Spleen Anemia Sickle Cell Platelet Factor 4 Internal medicine medicine Humans Platelet Platelet activation Aged business.industry Homozygote Heterozygote advantage Hematology General Medicine Middle Aged beta-Thromboglobulin medicine.disease Sickle cell anemia medicine.anatomical_structure Endocrinology Hemoglobinopathy Beta-thromboglobulin Immunology Female business Platelet factor 4 |
| Zdroj: | Blut. 61:245-247 |
| ISSN: | 1432-0584 0006-5242 |
| DOI: | 10.1007/bf01744139 |
| Popis: | To evaluate the platelet function in sickle cell syndromes we measured the beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) plasma values of 45 patients suffering from homozygous sickle cell anaemia (10) and sickle cell beta-thalassaemia (35) in steady state. The results were compared to those of 32 normal controls. Both the beta-TG and PF-4 levels were found to be significantly higher in patients than in controls but the beta-TG:PF-4 ratio was significantly lower in the patients group. This finding and the absence of any statistical correlation between platelet number and beta-TG or PF-4 indicate that platelets seem to be somehow activated in sickle cell syndromes, both in homozygotes and sickle cell/beta-thalassaemia heterozygotes. This platelet activation seems to exist even in steady state sickle cell disease patients, regardless of the functional status of the spleen. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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