Greater prevalence of comorbidities with increasing age: Cross-sectional analysis of chronic hepatitis B patients in Saudi Arabia
| Autor: | Faleh Z. Al-Faleh, Ayman A. Abdo, Waleed Al-Hamoudi, Waleed Alshumrani, Drifa Belhadi, Hamdan S. Alghamdi, Khalid Alswat, Abdullah S. Alghamdi, Mohammed A. Babatin, Faisal M. Sanai, Faisal Batwa, Khalid Albeladi, Yaser Dahlan, Ibrahim Altraif, Mona H Ismail, Abduljaleel M. Alalwan, Abdulrahman Aljumah, Victor Genestier |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Cross-sectional study Population Saudi Arabia medicine.disease_cause Hepatitis b surface antigen Comorbidities 03 medical and health sciences Liver disease 0302 clinical medicine Chronic hepatitis Internal medicine medicine lcsh:RC799-869 education Hepatitis B virus education.field_of_study Adult patients business.industry High mortality Gastroenterology medicine.disease treatment patterns 030220 oncology & carcinogenesis lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology business hepatitis B virus |
| Zdroj: | The Saudi Journal of Gastroenterology, Vol 25, Iss 3, Pp 194-200 (2019) |
| ISSN: | 1319-3767 |
| Popis: | Background/Aims: Middle Eastern countries, including Saudi Arabia to some extent, are endemic for chronic hepatitis B (CHB) infection which could be associated with high mortality and comorbidities risk. However, limited data characterizing this CHB population exists. Our aim was to characterize and compare CHB patients in 2015 with those in 2010 and 2012 in Saudi Arabia. Patients and Methods: We conducted and compared three cross-sectional analyses of adult patients with CHB defined as either positive hepatitis B surface antigen or documented CHB history in 2010, 2012, and 2015. Data were accessed from the multicenter Systematic Observatory Liver Disease Registry (SOLID). Results: A total of 765 CHB patients were identified in 2010 (n = 274), 2012 (n = 256), and 2015 (n = 235). Median age was significantly higher in 2015 (47 years) compared to 2010 and 2012 (42 years;P < 0.05). The proportions of patients with hepatocellular carcinoma (range 1–12%) and cirrhosis (range 5–23%) were significantly higher in 2015 compared to 2010 and 2012 (P < 0.05). Compared to 2010, patients in 2015 had significantly (P < 0.05) higher prevalence of coronary artery disease (10% vs. 4%) and hyperbilirubinemia (18% vs. 9%). Although not significant, there was a numerical increase in 2015 in chronic kidney disease (9% vs. 7% in 2010;P= 0.559) and hepatic steatosis (32% vs. 25% in 2010;P= 0.074). Significantly more patients in 2015 (P < 0.05) were treatment experienced (23% vs. 5% in 2010/2012) and switched treatment (17% vs. 1–2% in 2010/2012). Conclusions: Between 2010 and 2015, the CHB population in Saudi Arabia had significantly aged and was more likely to develop liver disease sequelae and other comorbidities. |
| Databáze: | OpenAIRE |
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