Lycopene reduced gene expression of steroid targets and inflammatory markers in normal rat prostate
| Autor: | Willi Hunziker, Athanasios Denelavas, Volker Spitzer, Karin Wertz, Angelika Herzog, Ulrich Siler, Petra Buchwald Hunziker, Regina Goralczyk, Nicole Seifert |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Health Status Down-Regulation Immunoglobulins Receptors Fc Biology Biochemistry Proinflammatory cytokine chemistry.chemical_compound Basal (phylogenetics) Lycopene Prostate Internal medicine Gene expression Genetics medicine Animals Insulin-Like Growth Factor I Receptor Molecular Biology Carotenoid chemistry.chemical_classification Inflammation Androgen Carotenoids Rats medicine.anatomical_structure Endocrinology chemistry Gene Expression Regulation Androgens Cytokines Biomarkers Biotechnology Signal Transduction |
| Zdroj: | FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 19(2) |
| ISSN: | 1530-6860 |
| Popis: | Epidemiological evidence links consumption of lycopene, the red carotenoid of tomato, to reduced prostate cancer risk. We investigated the effect of lycopene in normal prostate tissue to gain insight into the mechanisms, by which lycopene can contribute to primary prostate cancer prevention. We supplemented young rats with 200 ppm lycopene for up to 8 wk, measured the uptake into individual prostate lobes, and analyzed lycopene-induced gene regulations in dorsal and lateral lobes after 8 wk of supplementation. Lycopene accumulated in all four prostate lobes over time, with all-trans lycopene being the predominant isoform. The lateral lobe showed a significantly higher total lycopene content than the other prostate lobes. Transcriptomics analysis revealed that lycopene treatment mildly but significantly reduced gene expression of androgen-metabolizing enzymes and androgen targets. Moreover, local expression of IGF-I was decreased in the lateral lobe. Lycopene also consistently reduced transcript levels of proinflammatory cytokines, immunoglobulins, and immunoglobulin receptors in the lateral lobe. This indicates that lycopene reduced inflammatory signals in the lateral prostate lobe. In summary, we show for the first time that lycopene reduced local prostatic androgen signaling, IGF-I expression, and basal inflammatory signals in normal prostate tissue. All of these mechanisms can contribute to the epidemiologically observed prostate cancer risk reduction by lycopene. |
| Databáze: | OpenAIRE |
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