Environmental modifiable risk factors for multiple sclerosis: Report from the 2016 ECTRIMS focused workshop
| Autor: | Amato, Maria Pia, Derfuss, Tobias, Hemmer, Bernard, Liblau, Roland, Montalban, Xavier, Soelberg Sørensen, Per, Miller, David H, Alfredsson, Lars, Aloisi, Francesca, Ascherio, Alberto, Baldin, Elisa, Bjørnevik, Kjetil, Comabella, Manuel, Correale, Jorge, Cortese, Marianna, D’Hooghe, Marie, Ghezzi, Angelo, Gold, Julian, Hellwig, Kerstin, Hemmer, Bernhard, Koch-Henricksen, Nils, Langer Gould, Annette, Linker, Ralf, Lolli, Francesco, Lucas, Robyn, Lünemann, Jan, Magyari, Melinda, Massacesi, Luca, Miller, Ariel, Monteyne, Philippe, Mowry, Ellen, Münz, Christian, Nielsen, Nete M, Olsson, Tomas, Oreja-Guevara, Celia, Otero, Susana, Pugliatti, Maura, Reingold, Stephen, Riise, Trond, Robertson, Neil, Salvetti, Marco, Sidhom, Youssef, Smolders, Joost, Sollid, Ludvig, Steiner, Israel, Stenager, Egon, Sundstrom, Peter, Taylor, Bruce V, Tremlett, Helen, Trojano, Maria, Uccelli, Antonio, Waubant, Emmanuelle, Wekerle, Hartmut |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
comorbidities environmental risk factors infections lifestyle multiple sclerosis vitamin D neurology neurology (clinical) medicine.medical_specialty Disease 03 medical and health sciences 0302 clinical medicine medicine Demyelinating disease Vitamin D and neurology Genetic predisposition Intensive care medicine business.industry Multiple sclerosis Experimental autoimmune encephalomyelitis medicine.disease 3. Good health risk factor multiple sclerosis 030104 developmental biology Clinical research Neurology Etiology Physical therapy Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Multiple Sclerosis Journal. 24:590-603 |
| ISSN: | 1477-0970 1352-4585 |
| DOI: | 10.1177/1352458516686847 |
| Popis: | Multiple sclerosis (MS) is an inflammatory and neurodegenerative demyelinating disease of the central nervous system (CNS), most likely autoimmune in origin, usually beginning in early adulthood. The aetiology of the disease is not well understood; it is viewed currently as a multifactorial disease which results from complex interactions between genetic predisposition and environmental factors, of which a few are potentially modifiable. Improving our understanding of these factors can lead to new and more effective approaches to patient counselling and, possibly, prevention and management of the disease. The 2016 focused workshop of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) addressed the topic of environmental, modifiable risk factors for MS, gathering experts from around the world, to collate experimental and clinical research into environmental factors that have been associated with the disease onset and, in a few cases, disease activity and progression. A number of factors, including infections, vitamin D deficiency, diet and lifestyle factors, stress and comorbidities, were discussed. The meeting provided a forum to analyse available evidence, to identify inconsistencies and gaps in current knowledge and to suggest avenues for future research. |
| Databáze: | OpenAIRE |
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