Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine
| Autor: | Lauren E. Woodard, Gary H. Posner, Bryan T. Mott, Nirbhay Kumar, Vandana Singhal, Theresa A. Shapiro |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Drug
Trioxane medicine.medical_treatment media_common.quotation_subject Pharmaceutical Science lcsh:Medicine lcsh:RS1-441 antimalarial monomers and dimmers Pharmacology Article lcsh:Pharmacy and materia medica chemistry.chemical_compound Drug Discovery medicine Artemether Artemisinin silylamide trioxanes media_common Chemotherapy business.industry Mefloquine lcsh:R medicine.disease Mefloquine Hydrochloride chemistry single dose oral cure Molecular Medicine business Malaria medicine.drug |
| Zdroj: | Pharmaceuticals, Vol 2, Iss 3, Pp 228-235 (2009) Pharmaceuticals; Volume 2; Issue 3; Pages: 228-235 Pharmaceuticals |
| ISSN: | 1424-8247 |
| Popis: | Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield. Two of these new chemical entities completely cured malaria-infected mice at a single oral dose of only 8 mg/kg combined with 24 mg/kg of mefloquine hydrochloride. The high efficacy of this ACT chemotherapy is considerably better than the efficacy using the popular trioxane drug artemether plus mefloquine hydrochloride. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|