Mouse models of PIK3CA mutations: one mutation initiates heterogeneous mammary tumors
| Autor: | Mohamed Bentires-Alj, Shany Koren |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Genetically modified mouse
Class I Phosphatidylinositol 3-Kinases Mammary gland Mutation Missense Mice Transgenic P110α Biology medicine.disease_cause Biochemistry Pathogenesis 03 medical and health sciences Mice Phosphatidylinositol 3-Kinases 0302 clinical medicine Breast cancer medicine Animals Humans Molecular Biology PI3K/AKT/mTOR pathway 030304 developmental biology Genetics 0303 health sciences Mammary Neoplasms Experimental Cell Biology medicine.disease 3. Good health medicine.anatomical_structure Drug Resistance Neoplasm 030220 oncology & carcinogenesis Genetically Engineered Mouse Cancer research Female Tumor Suppressor Protein p53 Carcinogenesis |
| Zdroj: | The FEBS journal. 280(12) |
| ISSN: | 1742-4658 |
| Popis: | The phosphoinositide 3-kinase (PI3K) signaling pathway is crucial for cell growth, proliferation, metabolism, and survival, and is frequently deregulated in human cancer, including ~ 70% of breast tumors. PIK3CA, the gene encoding the catalytic subunit p110α of PI3K, is mutated in ~ 30% of breast cancers. However, the exact mechanism of PIK3CA-evoked breast tumorigenesis has not yet been defined. Genetically engineered mouse models are valuable for examining the initiation, development and progression of cancer. Transgenic mice harboring hotspot mutations in p110α have helped to elucidate breast cancer pathogenesis and increase our knowledge about molecular and cellular alterations in vivo. They are also useful for the development of therapeutic strategies. Here, we describe current mouse models of mutant PIK3CA in the mammary gland, and discuss differences in tumor latency and pathogenesis. |
| Databáze: | OpenAIRE |
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