Dehydroxymethylepoxyquinomicin (DHMEQ) can suppress tumour necrosis factor-α production in lipopolysaccharide-injected mice, resulting in rescuing mice from death in vivo
| Autor: | Kazuo Umezawa, Kazunari Kaneko, Junji Takaya, Tomohiko Shimo, Shoichiro Taniuchi, Mitsuhiko Okigaki, Yasushi Adachi, Susumu Ikehara |
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| Rok vydání: | 2011 |
| Předmět: |
Lipopolysaccharides
Male Necrosis Translational Studies Lipopolysaccharide Interleukin-1beta Immunology Apoptosis Endotoxin shock Mice chemistry.chemical_compound In vivo Animals Immunology and Allergy Medicine RNA Messenger Beneficial effects Cells Cultured Cell Proliferation Cell Nucleus Cyclohexanones Interleukin-6 Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha business.industry NF-kappa B Shock Septic In vitro Mice Inbred C57BL chemistry Benzamides lipids (amino acids peptides and proteins) Tumor necrosis factor alpha medicine.symptom business Spleen |
| Zdroj: | Clinical and Experimental Immunology. 166:299-306 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.2011.04475.x |
| Popis: | Summary Dehydroxymethylepoxyquinomicin (DHMEQ), a new nuclear factor (NF)-κB inhibitor, has several beneficial effects, including the suppression of tumour growth and anti-inflammatory effects. DHMEQ can also suppress the production of tumour necrosis factor (TNF)-α induced by lipopolysaccharide (LPS) in vitro. In the present study, we examine the effects of DHMEQ on TNF-α production in vivo and on the survival of mice injected with LPS. When DHMEQ was injected into mice 2 h before LPS injection, the survival of the LPS-injected mice was prolonged. When DHMEQ was injected twice (2 h before LPS injection and the day after LPS injection), all the mice were rescued. The injection of DHMEQ 1 h after LPS injection and the day after LPS injection also resulted in the rescue of all mice. The serum levels of TNF-α in the mice that received both LPS and DHMEQ were suppressed compared to the mice that received only LPS. These results suggest that DHMEQ can be utilized for the prevention and treatment of endotoxin shock. |
| Databáze: | OpenAIRE |
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