Effects of maternal bisphenol A diglycidyl ether exposure during gestation and lactation on behavior and brain development of the offspring
Autor: | Masato Asanuma, Jonathan Smart, Ikuko Miyazaki, Kyle E. Quin, Kazumasa Zensho, Mika Takeshima, Rei Arai, Kanau Sonobe, Nami Isooka, Ryo Kikuoka, Hidemaru Funakoshi |
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Rok vydání: | 2020 |
Předmět: |
Male
Anxiety Toxicology Open field chemistry.chemical_compound Mice Pregnancy Lactation Food Preserved Bisphenol A diglycidyl ether 0303 health sciences Mice Inbred ICR Behavior Animal Brain Cell Differentiation 04 agricultural and veterinary sciences General Medicine Anxiety behavior 040401 food science Brain development medicine.anatomical_structure Breast Feeding Neuronal differentiation Maternal Exposure Gestation Female Neurite Offspring Subventricular zone Food Contamination Biology Andrology 03 medical and health sciences 0404 agricultural biotechnology Dogs medicine Animals Humans Epoxy resin Benzhydryl Compounds 030304 developmental biology Fetus Body Weight Diet Disease Models Animal chemistry Epoxy Compounds Food Science |
Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 138 |
ISSN: | 1873-6351 |
Popis: | Bisphenol A diglycidyl ether (BADGE) is an epoxy resin used for the inner coating of canned food and beverages. BADGE can easily migrate from the containers and become a contaminant. In this study, we examined the effects of BADGE exposure to the dams on the behavioral, structural, and developmental abnormalities in the offspring. Female pregnant mice were fed with a diet containing BADGE (0.15 or 1.5 mg/kg/day) during gestation and lactation periods. In an open field test, the time spent in the corner area significantly increases in male mice of high-dose BADGE group at 5 weeks old. The histological analysis using offspring brain at postnatal day 1 delivered from BADGE (1.5 mg/kg/day)-treated dams demonstrates that positive signals of Forkhead box P2- and COUP-TF interacting protein 2 are restricted in each cortical layer, but not in the control brain. In addition, the maternal BADGE exposure reduces nestin-positive fibers of the radial glia and T-box transcription factor 2-positive intermediate progenitors in the inner subventricular zone. Furthermore, a direct BADGE exposure promotes neurite outgrowth and neuronal connection in the primary cultured cortical neurons. These data suggest that maternal BADGE exposure can accelerate neuronal differentiation in fetuses and induce anxiety-like behavior in juvenile mice. |
Databáze: | OpenAIRE |
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