Sesquiterpenoids from the seeds of Sarcandra glabra and the potential anti-inflammatory effects
| Autor: | Ling-Yi Kong, Rui-Jun Li, Jun Luo, Peng Wang, Saimijiang Yaermaimaiti |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Stereochemistry
medicine.drug_class Anti-Inflammatory Agents Nitric Oxide 010402 general chemistry Ring (chemistry) 01 natural sciences Anti-inflammatory Nitric oxide Magnoliopsida Mice chemistry.chemical_compound Drug Discovery medicine Animals Sesquiterpenes Eudesmane Organic chemistry No production Furans Sarcandra glabra Pharmacology Molecular Structure 010405 organic chemistry Macrophages General Medicine 0104 chemical sciences RAW 264.7 Cells chemistry Seeds Sesquiterpenes Derivative (chemistry) Drugs Chinese Herbal |
| Zdroj: | Fitoterapia. 111:7-11 |
| ISSN: | 0367-326X |
| Popis: | Five new sesquiterpenoids, including two linderanes (1-2) and three eudesmanes (3-5) were isolated from the seeds of Sarcandra glabra. Their structures and relative configurations were established by spectroscopic data analysis. 1 was a rare linderane derivative having an 18-membered triester ring which is a common characteristic in linderane dimers. Compounds 1-5 were investigated for their inhibitory effects on NO production in LPS-induced macrophages and 1 showed moderate bioactivity. |
| Databáze: | OpenAIRE |
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