Fungi.guru: Comparative genomic and transcriptomic resource for the fungi kingdom
| Autor: | Jia Rong Moo, Wei Song Seetoh, Tong Ling Chan, Vanessa Lunardi, Cherlyn Xin’Er Chua, Riccardo Delli-Ponti, Zoe Hui Xin Chen, Marek Mutwil, Shan Chun Lim, Kenny Koh, Jace Koh, Rinta P. Reji, Tuck Choy Fong, Jonathan Wei Xiong Ng, Yuen Shan Lim, Ann Don Low, Natasha Cassandra Chee, Ryanjit Singh Kairon, Herman Foo, Irene Julca, Jolyn Jia Jia Lim, Dhira Anindya Putri, Nhi Le Uyen Nguyen, Ker Min Hee, Sriya Mulupuri, Margaret Xuan Zhao, Edbert Edric Rodrigues, Erielle Marie Fajardo Villanueva, Janice Wan Zhen Ng |
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| Přispěvatelé: | School of Biological Sciences |
| Rok vydání: | 2020 |
| Předmět: |
Pyricularia
lcsh:Biotechnology Biophysics Expression Computational biology Secondary metabolite Biochemistry Database 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Structural Biology lcsh:TP248.13-248.65 Genetics medicine Gene family Gene 030304 developmental biology ComputingMethodologies_COMPUTERGRAPHICS 0303 health sciences Gliotoxin biology fungi Fungi Biological sciences [Science] food and beverages biology.organism_classification Co-expression Computer Science Applications Coprinopsis cinerea Metabolism chemistry 030220 oncology & carcinogenesis Identification (biology) Gene function Function (biology) Biotechnology medicine.drug Research Article |
| Zdroj: | Computational and Structural Biotechnology Journal Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 3788-3795 (2020) |
| ISSN: | 2001-0370 |
| Popis: | Graphical abstract The fungi kingdom is composed of eukaryotic heterotrophs, which are responsible for balancing the ecosystem and play a major role as decomposers. They also produce a vast diversity of secondary metabolites, which have antibiotic or pharmacological properties. However, our lack of knowledge of gene function in fungi precludes us from tailoring them to our needs and tapping into their metabolic diversity. To help remedy this, we gathered genomic and gene expression data of 19 most widely-researched fungi to build an online tool, fungi.guru, which contains tools for cross-species identification of conserved pathways, functional gene modules, and gene families. We exemplify how our tool can elucidate the molecular function, biological process and cellular component of genes involved in various biological processes, by identifying a secondary metabolite pathway producing gliotoxin in Aspergillus fumigatus, the catabolic pathway of cellulose in Coprinopsis cinerea and the conserved DNA replication pathway in Fusarium graminearum and Pyricularia oryzae. The tool is available at www.fungi.guru. |
| Databáze: | OpenAIRE |
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