Antibodies reactive with neurons in SLE patients with neuropsychiatric manifestations
| Autor: | G.J. Friou, F.P. Quismorio |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Cytoplasm
Immunology Group ii Guinea Pigs Fluorescent Antibody Technique Antibodies Serology Antigen-Antibody Reactions Neurologic Manifestations medicine Immunology and Allergy Animals Humans Lupus Erythematosus Systemic Neurologic disease skin and connective tissue diseases Neurons Systemic lupus erythematosus biology business.industry Incidence (epidemiology) General Medicine DNA medicine.disease Titer biology.protein High incidence Rabbits Antibody business |
| Zdroj: | International archives of allergy and applied immunology. 43(5) |
| ISSN: | 0020-5915 |
| Popis: | Antibodies reactive with the cytoplasm of neurons were found in 41% of SLE patients with active neurologic disease (group I). In contrast, these antibodies were found in 24% of lupus patients with past history of neurologic disease (group II), in 9% in those without a history of neurologic involvement (group III) and 0.9% in non-SLE controls, Although reactive with neurons, these antibodies were non-organ specific since they reacted with cells of non-nervous origin. The incidence and titer of antibodies to DNA and DNA-protein were however the same in the three groups of SLE patients suggesting that the high incidence of anti-cytoplasmic antibodies in group I may be specifically related to neuropsychiatric involvement rather than an expression of increased serologic reactivity of acutely ill lupus patients. |
| Databáze: | OpenAIRE |
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