| Autor: |
Tobias A. Bauer, Jonas Schramm, Federico Fenaroli, Svenja Siemer, Christine I. Seidl, Christine Rosenauer, Regina Bleul, Roland H. Stauber, Kaloian Koynov, Michael Maskos, Matthias Barz |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Advanced Materials, 35(21):2210704 |
| DOI: |
10.1002/adma.202210704 |
| Popis: |
Translating innovative nanomaterials to medical products requires efficient manufacturing techniques that enable large-scale high-throughput synthesis and high reproducibility. Drug carriers in medicine embrace a complex subset of tasks calling for multi-functionality. Here, we report the synthesis of pro-drug-loaded core cross-linked polymeric micelles (CCPMs) in a continuous flow process, which combines the commonly separated steps of micelle formation, core cross-linking, functionalization, and purification into a single process. Redox-responsive CCPMs are formed from thiol-reactive polypept(o)ides of polysarcosine-block-poly(S-ethylsulfonyl-l-cysteine) and functional cross-linkers based on dihydrolipoic acid hydrazide for pH-dependent release of paclitaxel. The precisely controlled microfluidic self-assembly and purification process allows the production of spherical micelles (Dh = 35 nm) with low polydispersity values (PDI |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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