Profiles of lipids, blood pressure and weight changes among premenopausal Chinese breast cancer patients after adjuvant chemotherapy

Autor: Giok S. Liem, Rita Y. W. Ng, Elizabeth Pang, Joyce J. S. Suen, Winnie Yeo, Frankie Mo, Jane Koh, Claudia H. W. Yip, Herbert H. Loong, Nelson L.S. Tang, Christopher C. H. Yip
Rok vydání: 2016
Předmět:
Oncology
Cytotoxic
Blood Pressure
Overweight
Weight Gain
Body Mass Index
0302 clinical medicine
030212 general & internal medicine
Cholesterols
lcsh:Public aspects of medicine
Obstetrics and Gynecology
General Medicine
Middle Aged
Lipids
Menopause
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
Hypertension
Female
Taxoids
medicine.symptom
medicine.drug
Research Article
Adult
Bridged-Ring Compounds
medicine.medical_specialty
China
Antineoplastic Agents
Breast Neoplasms
lcsh:Gynecology and obstetrics
03 medical and health sciences
Young Adult
Breast cancer
Internal medicine
medicine
Humans
Obesity
lcsh:RG1-991
Retrospective Studies
business.industry
Retrospective cohort study
lcsh:RA1-1270
medicine.disease
Tamoxifen
Reproductive Medicine
Premenopause
Dyslipidemia
business
Body mass index
Weight gain
Zdroj: BMC Women's Health
BMC Women's Health, Vol 17, Iss 1, Pp 1-11 (2017)
ISSN: 1472-6874
Popis: Background Adjuvant chemotherapy improves outcome of patients with early breast cancer. However, chemotherapy may be associated with long term toxicities. In this retrospective cohort study, the objectives were to determine body weight, body mass index (BMI), blood pressure and fasting lipids levels of young premenopausal Chinese breast cancer patients after adjuvant chemotherapy. Potential factors associated with these parameters were identified. Methods Eligibility criteria include premenopausal Chinese patients who were diagnosed to have stage I-III breast cancer within 3–10 years, age 2%; 52.1% were overweight/obese; 30.7% had hypertension. Abnormal total-cholesterol and LDL-cholesterol occurred in 34.3% and 56.1% respectively. On multivariate analyses, older age was associated with reduced risk while occurrence of CRA and having received taxane-containing regimens were associated with increased risk of weight gain. Oestrogen-receptor positivity was associated with reduced risk while overweight/obese statuses were associated with increased risk of hypertension. Use of tamoxifen was associated with reduced risk of abnormal LDL-cholesterol. Weight gain, overweight/obese, older age, progression to post/peri-menopausal status at study entry, having received corticosteroid premedication before adjuvant chemotherapy and having received taxane-containing adjuvant chemotherapy were associated with increased risk of dyslipidaemias. Conclusion Among young premenopausal Chinese breast cancer patients who had received adjuvant chemotherapy, the current study has revealed that although there was only a median weight gain of 1.8 kg, there was a nearly 60% increase in abnormal BMI. Further, a significant proportion of patients were detected to have hypertension and dyslipidaemias. Interventional studies with lifestyle modifications are warranted. Electronic supplementary material The online version of this article (doi:10.1186/s12905-017-0409-8) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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