Enjoying hobbies is related to desirable cardiovascular effects

Autor: Keishi Saihara, Shuichi Hamasaki, Hideki Okui, Etsuko Mizoguchi, Tsuyoshi Fukudome, Tetsuro Kataoka, Takuro Kubozono, Masakazu Ogawa, Akiko Yoshikawa, Takuro Takumi, Naoya Oketani, Nobuhiko Atsuchi, Yuichi Ninomiya, Koji Orihara, Takuro Shinsato, Hitoshi Ichiki, Sanemasa Ishida, Shoji Fujita, So Kuwahata, Kaai Tomita, Chuwa Tei
Rok vydání: 2008
Předmět:
Male
Pleasure
Time Factors
Vasodilator Agents
Kaplan-Meier Estimate
Coronary Angiography
Nitroglycerin
Risk Factors
Papaverine
Surveys and Questionnaires
Odds Ratio
Medicine
Aged
80 and over
Arteriosclerosis
Middle Aged
Prognosis
Coronary Vessels
Echocardiography
Doppler
Cardiac surgery
Vasodilation
medicine.anatomical_structure
Cardiovascular Diseases
Cardiology
Female
Cardiology and Cardiovascular Medicine
Artery
Adult
medicine.medical_specialty
Adolescent
Anterior Descending Coronary Artery
Risk Assessment
Disease-Free Survival
Young Adult
Internal medicine
Coronary Circulation
Humans
Life Style
Aged
Proportional Hazards Models
business.industry
Proportional hazards model
Hobbies
Odds ratio
medicine.disease
Confidence interval
Acetylcholine
Quality of Life
business
Risk Reduction Behavior
Mace
Stress
Psychological
Zdroj: Heart and vessels. 25(2)
ISSN: 1615-2573
Popis: An unhealthy lifestyle can increase the risk of cardiovascular disease. However, the mechanism by which lifestyle influences the development of cardiovascular disease remains unclear. Since coronary endothelial function is a predictor of cardiovascular prognosis, the goal of this study was to characterize the effect of enjoying hobbies on coronary endothelial function and cardiovascular outcomes. A total of 121 consecutive patients (76 men, 45 women) with almost normal coronary arteries underwent Doppler flow study of the left anterior descending coronary artery following sequential administration of papaverine, acetylcholine, and nitroglycerin. On the basis of responses to questionnaires, patients were divided into two groups; the Hobby group (n = 71) who enjoyed hobbies, and the Non-hobby group (n = 50) who had no hobbies. Cardiovascular outcomes were assessed at long-term follow-up using medical records or questionnaire surveys for major adverse cardiovascular events (MACE).The average follow-up period was 916 +/- 515 days. There were no significant differences in demographics when comparing the two groups. The percent change in coronary blood flow and coronary artery diameter induced by acetylcholine was significantly greater in the Hobby group than in the Non-hobby group (49% +/- 77% vs 25% +/- 37%, P0.05, 4% +/- 13% vs -3% +/- 20%, P0.05, respectively). The MACE rate was significantly lower in the Hobby group than in the Non-hobby group (P0.01). Enjoyment of hobbies was the only independent predictor of MACE (odds ratio 8.1 [95% confidence interval 1.60, 41.90], P = 0.01) among the variables tested. In the early stages of arteriosclerosis, enjoying hobbies may improve cardiovascular outcomes via its favorable effects on coronary endothelial function.
Databáze: OpenAIRE
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