Bone marrow mesenchymal stromal cells and olfactory ensheathing cells transplantation after spinal cord injury - a morphological and functional comparison in rats

Autor:	Xavier Navarro, Abel Torres-Espín, Elena Redondo-Castro, Joaquim Hernández
Rok vydání:	2014
Předmět:	Male Pathology medicine.medical_specialty Cell Survival Delayed time Ependymoglial Cells Neural Conduction Motor Activity Mesenchymal Stem Cell Transplantation Rats Sprague-Dawley Cell therapy Reflex medicine Animals Thermosensing Muscle Skeletal Spinal cord injury Cells Cultured Spinal Cord Injuries business.industry General Neuroscience Mesenchymal stem cell Recovery of Function Evoked Potentials Motor medicine.disease Olfactory Bulb Transplantation Disease Models Animal Electrophysiology medicine.anatomical_structure Spinal Cord Touch Female Sensorimotor Cortex Olfactory ensheathing glia Bone marrow business
Zdroj:	European Journal of Neuroscience. 39:1704-1717
ISSN:	0953-816X
Popis:	Cell therapy for spinal cord injury (SCI) is a promising strategy for clinical application. Both bone marrow mesenchymal stromal cells (MSCs; also known as bone marrow-derived 'mesenchymal stem cells') and olfactory ensheathing cells (OECs) have demonstrated beneficial effects following transplantation in animal models of SCI. However, due to the large number of affecting parameters that determine the therapy success and the lack of methodological consensus, the comparison of different works is difficult. Therefore, we compared the effects of MSC and OEC transplants at early or delayed time after a spinal cord contusion injury in the rat. Functional outcomes for locomotion, sensory perception and electrophysiological responses were assessed. Moreover, the grafted cells survival and the amount of cavity and spared tissue were studied. The findings indicate that grafted cells survived until 7 days post-injection, but markedly disappeared in the following 2 weeks. Despite the low survival of the cells, MSC and OEC grafts provided tissue protection after early and delayed transplantation. Nevertheless, only acute MSC grafts improved locomotion recovery in treadmill condition and electrophysiological outcomes with respect to the other injured groups. These results, together with previous works, indicate that the MSC seem a better option than OEC for treatment of contusion injuries.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a8b4e2b959e7b6ff73f851b295485a https://doi.org/10.1111/ejn.12542 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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