Autonomic balance determines the severity of COVID-19 courses
| Autor: | D. Stefanovic, M. Leitzke, J.-J. Meyer, S. Schimpf, Peter Schönknecht |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Stimulation Cytokine storm 03 medical and health sciences 0302 clinical medicine Cholinergic anti-inflammatory pathway medicine Interleukin 8 Vagal nerve Vagal tone Interleukin 6 Heart rate variability General Environmental Science NF-κB pathway biology business.industry COVID-19 Hypothesis medicine.disease 030104 developmental biology Cytokine Immunology biology.protein General Earth and Planetary Sciences Cholinergic business 030217 neurology & neurosurgery |
| Zdroj: | Bioelectronic Medicine |
| ISSN: | 2332-8886 |
| Popis: | COVID-19 has left mankind desperately seeking how to manage dramatically rising infection rates associated with severe disease progressions. COVID-19 courses range from mild symptoms up to multiple organ failure and death, triggered by excessively high serum cytokine levels (IL 1β, IL 6, TNF α, IL 8). The vagally driven cholinergic anti-inflammatory pathway (CAP) stops the action of nuclear factor κB (NF-κB), the transcriptional factor of pro-inflammatory cytokines. Thus, well-balanced cytokine release depends on adequate vagal signaling. Coronaviruses replicate using NF-κB transcriptional factor as well. By degrading the cytoplasmatic inhibitor of NF-κB subunits (IκB), coronaviruses induce unrestricted NF-κB expression accelerating both, virus replication and cytokine transcription.We hypothesize that CAP detriment due to depressed vagal tone critically determines the severity of COVID-19. |
| Databáze: | OpenAIRE |
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