Higher body mass index is associated with increased lung stiffness and less airway obstruction in individuals with asthma and fixed airflow obstruction
| Autor: | Sabine C. Zimmermann, Farid Sanai, Katrina O. Tonga, Sandra Rutting, Cindy Thamrin, David G. Chapman, Gregory G. King, Tanya Badal |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty lcsh:Medicine macromolecular substances Pulmonary compliance Airflow obstruction 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine 030212 general & internal medicine Asthma Lung business.industry lcsh:R digestive oral and skin physiology Original Research Letters food and beverages respiratory system Airway obstruction medicine.disease respiratory tract diseases medicine.anatomical_structure 030228 respiratory system Cardiology business Body mass index |
| Zdroj: | ERJ Open Research article-version (VoR) Version of Record ERJ Open Research, Vol 7, Iss 1 (2021) |
| ISSN: | 2312-0541 |
| DOI: | 10.1183/23120541.00336-2020 |
| Popis: | Persistent or fixed airflow obstruction (FAO) is prevalent in up to 60% of patients with severe asthma [1] and is associated with older age, more rapid decline in lung function and increased symptoms [1–3]. The underlying mechanisms of FAO in asthma are unknown, but growing evidence suggests that parenchymal changes resulting in loss of elastic recoil and decreased lung stiffness (i.e. increased lung compliance) contribute to FAO [2, 4]. In a recent study of older asthma patients with FAO, decreased lung stiffness was the sole predictor of more severe airflow obstruction, as measured by reduced forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio [2]. Higher body mass index (BMI) is associated with less severe airway obstruction in older asthma patients with fixed airflow obstruction. This is potentially mediated through BMI-related mechanisms that increase lung stiffness (i.e. reduce lung compliance). https://bit.ly/3jBwCNy |
| Databáze: | OpenAIRE |
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