Efficacy and tolerability of high-dose phenobarbital in children with focal seizures
| Autor: | Ayuko Igarashi, Michihiko Takasu, Akihisa Okumura, Mika Nakazawa, Shinpei Abe, Mitsuru Ikeno, Eri Nakahara, Toshiaki Shimizu |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Phenobarbital treatment Pharmacology 03 medical and health sciences Epilepsy 0302 clinical medicine Developmental Neuroscience Seizures Humans Medicine Child Surgical treatment Retrospective Studies Seizure frequency business.industry 030208 emergency & critical care medicine General Medicine Phenobarbital level medicine.disease Treatment Outcome Tolerability Child Preschool Phenobarbital Anesthesia Pediatrics Perinatology and Child Health Anticonvulsants Female Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Brain and Development. 38:414-418 |
| ISSN: | 0387-7604 |
| Popis: | We retrospectively reviewed the outcomes of children with focal epilepsy treated with oral high-dose phenobarbital.We reviewed data on children (aged15 years) with focal seizures treated with high-dose phenobarbital (5 mg/kg/day to maintain a target serum level40 μg/mL) for at least 6 months. Seizure frequency was evaluated after phenobarbital titration, and 1 and 2 years after high-dose phenobarbital treatment commenced. Treatment was judged effective when seizure frequencies fell by ⩾75%.Seven boys and eight girls were treated. The median age at commencement of high-dose phenobarbital therapy was 30 months. The maximal serum phenobarbital level ranged from 36.5 to 62.9 μg/mL. High-dose PB was effective in seven. In two patients, treatment was transiently effective, but seizure frequency later returned to the baseline. High-dose PB was ineffective in six. No significant association between effectiveness and any clinical variable was evident. Drowsiness was recorded in nine patients, but no patient developed a behavioral problem or hypersensitivity.Oral high-dose phenobarbital was effective in 7 of 15 patients with focal epilepsy and well tolerated. High-dose PB may be useful when surgical treatment is difficult. |
| Databáze: | OpenAIRE |
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