μ-Chain secretion by peripheral blood lymphocytes in μ-chain disease; functional and ultrastructural characterization of cells associated with μ-chain production
| Autor: | O. Wetter, W. Leene, K. H. Linder |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
biology
Immunoglobulin mu-Chains General Medicine Middle Aged medicine.disease Molecular biology Heavy chain disease Cell biology chemistry.chemical_compound Monomer chemistry Cytoplasm medicine biology.protein Ultrastructure Humans Immunoglobulin heavy chain Female Secretion Lymphocytes Antibody Immunoglobulin Heavy Chains Heavy Chain Disease |
| Zdroj: | European Journal of Cancer (1965). 13:985-992 |
| ISSN: | 0014-2964 |
| Popis: | The course of secretion of immunoglobulin (Ig) μ-chain secretion by cultured peripheral blood lymphocytes in a case of heavy chain disease has been studied. It has been found that μ-chain protein is secreted primarily as a monomer. Dimers and polymers of μ-chain protein found in the serum of this patient are of secondary i.e. post-synthetic origin. By comparison of cytoplasmic and culture supernatant protein it has been found that metabolically inert deposits of μ-chain protein in aggregated form are present within the cultured cells. By ultrastructure studies these cells were classified as small lymphoid cells. The cells associated with μ-chain secretion in this patient exhibit distinct functional and ultrastructural features and possibly are arrested at a differentiation stage at which surface Ig synthesis is initiated. |
| Databáze: | OpenAIRE |
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