SAT-003 Prolactin Is Expressed in Uterine Leiomyomas and May Promote Their Growth
| Autor: | Manisha Taya, Divya Kumar, Ifunanya Okeke, Ankit Dahal, Andrea Amitrano, Alessandra R DiMauro, Bala Bhagavath, Christina Seger, Irina Lerman, Stephen R. Hammes |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Uterine leiomyoma business.industry Endocrinology Diabetes and Metabolism musculoskeletal system female genital diseases and pregnancy complications Prolactin Endocrinology Internal medicine medicine Reproductive Endocrinology Clinical Studies in Female Reproduction I business neoplasms AcademicSubjects/MED00250 hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of the Endocrine Society |
| ISSN: | 2472-1972 |
| DOI: | 10.1210/jendso/bvaa046.657 |
| Popis: | Uterine leiomyomas, commonly referred to as fibroids, are benign, estrogen sensitive smooth muscle tumors that occur in the myometrium of the uterine wall. Leiomyomas are common, as it is estimated that 60% of reproductive-aged women are affected, and 80% of women develop leiomyomas during their lifetime. In fact, uterine leiomyomas are the leading cause of abnormal menstrual bleeding or menstrual pain, as well as the number one reason for hysterectomy. Novel treatment options are necessary as current treatments are limited to anti-estrogen therapy or hysterectomy. Estrogen is known to have an effect on the etiology of leiomyomas, but little is known about the proliferative roles of other hormones in leiomyomas. One hormone of interest is prolactin (PRL) which is primarily secreted from the pituitary to regulate lactation, but has been linked to proliferation in breast cancer, perhaps via local prolactin production in breast tissue. With this background, we examined local PRL production and its effects on leiomyomas. RNA isolation and quantitative PCR of human leiomyoma samples (n=20) relative to adjacent myometrium in the same patients confirmed significant expression of both PRL (p= 0.0028) and dopamine receptor D2, a known regulator of PRL production in the pituitary (p |
| Databáze: | OpenAIRE |
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