Rates of recurrent preterm birth by maternal body habitus in women receiving 17α-hydroxyprogesterone caproate
| Autor: | Annelee Boyle, Maisa Feghali, Julia Timofeev, Rita W. Driggers, Niki Istwan, Debbie Rhea |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Overweight Body Mass Index Cohort Studies Young Adult Pregnancy Recurrence Statistical significance 17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterones medicine Humans Obesity Retrospective Studies Progesterone Congeners Obstetrics business.industry Infant Newborn nutritional and metabolic diseases Obstetrics and Gynecology Retrospective cohort study medicine.disease Pregnancy Complications Pediatrics Perinatology and Child Health Cohort Premature Birth Gestation Female medicine.symptom business Body mass index Cohort study |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 26:881-884 |
| ISSN: | 1476-4954 1476-7058 |
| DOI: | 10.3109/14767058.2013.765847 |
| Popis: | To examine the influence of maternal pre-pregnancy body mass index (BMI) on the rates of recurrent spontaneous preterm birth (SPTB) in women receiving 17α-hydroxyprogesterone caproate (17P).Retrospective analysis of a cohort of 6253 women with a singleton gestation and prior SPTB enrolled in 17P home administration program between 16.0 and 26.9 weeks. Data were grouped by pre-pregnancy BMI (lean18.5 kg/m(2), normal 18.5-24.9 kg/m(2), overweight 25-29.9 kg/m(2) and obese ≥30.0 kg/m(2)). Delivery outcomes were compared using χ(2) and Kruskal-Wallis tests with statistical significance set at p 0.05.SPTB28 weeks was significantly lower in normal weight women. Rates of recurrent SPTB37 weeks were highest in the group with BMI18.5 kg/m(2). Lean gravidas were younger, more likely to smoke, and less likely to be African-American than those with normal or increased BMI. In logistic regression, after controlling for race and prior preterm birth28 weeks, the risk of SPTB37 weeks decreased 2% for every additional 1 kg/m(2) increase in BMI.Recurrent spontaneous preterm delivery37 weeks in patients on 17P is more common in lean women (BMI18.5 kg/m(2)), and less common in obese women (BMI ≥30 kg/m(2)) suggesting that the current recommended dosing of 17 P is adequate for women with higher BMI. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|