A Wireless FSCV Monitoring IC with Analog Background Subtraction and UWB Telemetry
| Autor: | Carlos I. Dorta-Quinones, Rajeev K. Dokania, Alycia Gailey, Xiao Wang, Manfred Lindau, Alyssa B. Apsel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Dopamine
Biomedical Engineering Analytical chemistry 02 engineering and technology 01 natural sciences Article Narrowband 0202 electrical engineering electronic engineering information engineering Animals Telemetry Electrical and Electronic Engineering Physics business.industry Dynamic range 020208 electrical & electronic engineering 010401 analytical chemistry Transmitter Electrical engineering Signal Processing Computer-Assisted Equipment Design Chip 0104 chemical sciences Equipment Failure Analysis Transmission (telecommunications) CMOS Modulation Antenna (radio) business Microelectrodes Wireless Technology Analog-Digital Conversion |
| Zdroj: | IEEE Transactions on Biomedical Circuits and Systems |
| Popis: | A 30- $\mu {\rm W}$ wireless fast-scan cyclic voltammetry monitoring integrated circuit for ultra-wideband (UWB) transmission of dopamine release events in freely-behaving small animals is presented. On-chip integration of analog background subtraction and UWB telemetry yields a 32-fold increase in resolution versus standard Nyquist-rate conversion alone, near a four-fold decrease in the volume of uplink data versus single-bit, third-order, delta-sigma modulation, and more than a 20-fold reduction in transmit power versus narrowband transmission for low data rates. The 1.5- ${\rm mm}^{2}$ chip, which was fabricated in 65-nm CMOS technology, consists of a low-noise potentiostat frontend, a two-step analog-to-digital converter (ADC), and an impulse-radio UWB transmitter (TX). The duty-cycled frontend and ADC/UWB-TX blocks draw 4 $\mu {\rm A}$ and 15 $\mu {\rm A}$ from 3-V and 1.2-V supplies, respectively. The chip achieves an input-referred current noise of 92 ${\rm pA}_{\rm rms}$ and an input current range of $\pm {430}~{\rm nA}$ at a conversion rate of 10 kHz. The packaged device operates from a 3-V coin-cell battery, measures 4.7 $\,\times\,$ 1.9 ${\rm cm}^{2}$ , weighs 4.3 g (including the battery and antenna), and can be carried by small animals. The system was validated by wirelessly recording flow-injection of dopamine with concentrations in the range of 250 nM to 1 $\mu {\rm M}$ with a carbon-fiber microelectrode (CFM) using 300-V/s FSCV. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|