Platelet reactions after interaction with cultured Plasmodium falciparum infected erythrocytes
| Autor: | E. M. Essien, Inyang Al, D. T. Okpako, O. Sodeinde |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Blood Platelets
Serotonin Erythrocytes Platelet Aggregation Plasmodium falciparum Biology Microbiology Thromboxane A2 chemistry.chemical_compound Cell–cell interaction parasitic diseases medicine Humans Platelet Cells Cultured Hematology biology.organism_classification In vitro Malaria Adenosine Diphosphate Red blood cell medicine.anatomical_structure chemistry Cell culture Immunology Thromboxane-A Synthase Dense granule |
| Zdroj: | British Journal of Haematology. 66:375-378 |
| ISSN: | 0007-1048 |
| DOI: | 10.1111/j.1365-2141.1987.00331.x-i1 |
| Popis: | Summary An in vitro model for studying the interaction between normal human platelets and Plasmodium falciparum infected erythrocytes in culture is described. After the interaction, changes in platelet function such as enhanced aggregation response to exogenous ADP and increased secretion of dense granule contents were reproduced. Some of these responses represented manifestations of platelet hypersensitivity described earlier in acute malaria infections in man and mice. Preliminary investigations of the mechanisms involved in such reactions revealed that ADP and thromboxane A2 mechanisms contributed about 79% and 18.5% of the enhanced aggregation response to exogenous stimuli in the system. |
| Databáze: | OpenAIRE |
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