Intracellular mRNA localization: motors move messages
| Autor: | Hille Tekotte, Ilan Davis |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Regulation of gene expression
Molecular Motor Proteins Dynein Myosin Type V Dyneins Kinesins macromolecular substances Biology Intracellular mRNA localization Cell biology DNA-Binding Proteins Microtubule Yeasts Translational regulation Genetics Molecular motor Trans-Activators Kinesin Animals Drosophila Proteins Drosophila RNA Messenger Cytoskeleton Transcription Factors |
| Zdroj: | Trends in genetics : TIG. 18(12) |
| ISSN: | 0168-9525 |
| Popis: | Intracellular mRNA localization is a common mechanism of post-transcriptional regulation of gene expression. In a wide range of organisms, mRNA localization coupled with translational regulation target the proteins to their site of function. Here, we describe recent exciting evidence that some mRNAs are transported as particles along the cytoskeleton by the molecular motors dynein, kinesin or myosin. We discuss the key questions of how localized mRNAs might be linked to motors and what determines their cytoplasmic destinations. |
| Databáze: | OpenAIRE |
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