Exosomal microRNAs in liquid biopsies: future biomarkers for prostate cancer
| Autor: | Rafael Sirera, S Crispi, Pablo Reclusa, Patrick Pauwels, Christian Rolfo, Marco Giallombardo, Anna Valentino, Carlos Camps |
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| Přispěvatelé: | Valentino, A., Reclusa Asiain, P., Sirera, R., Giallombardo, M., Camps, C., Pauwels, P., Crispi, S., Rolfo, C. |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
PCA3 Male Cancer Research Biomarker Exosome Liquid biopsies MiRNAs Prostate cancer Bioinformatics Exosomes 03 medical and health sciences 0302 clinical medicine Prostate Liquid biopsie microRNA Biomarkers Tumor Medicine Humans Liquid biopsy business.industry Liquid Biopsy Cancer Prostatic Neoplasms General Medicine medicine.disease Microvesicles MicroRNAs 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Human medicine business MiRNA |
| Zdroj: | Clinical and translational oncology |
| ISSN: | 1699-048X |
| Popis: | Prostate cancer is the second most diagnosed cancer in males in the world. Plasma quantification of prostate-specific antigen substantially improved the early detection of prostate cancer, but still lacks the required specificity. Clinical management of prostate cancer needs advances in the development of new non-invasive biomarkers, ameliorating current diagnosis and prognosis and guiding therapeutic decisions. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the post-transcriptional level. These miRNAs are expressed in the cells and are also present in cell-derived extracellular vesicles such as exosomes. Exosomes have been shown to act as mediators for cell to cell communication because of the regulatory functions of their content. High levels of exosomes are found in several body fluids from cancer patients and could be a potential source of non-invasive biomarkers. In this review, we summarize the diagnostic and prognostic utility of exosomal miRNAs in prostate cancer. |
| Databáze: | OpenAIRE |
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